The Replicative Fitness of Primary Human Immunodeficiency Virus Type 1 (HIV-1) Group M, HIV-1 Group O, and HIV-2 Isolates
نویسندگان
چکیده
منابع مشابه
The replicative fitness of primary human immunodeficiency virus type 1 (HIV-1) group M, HIV-1 group O, and HIV-2 isolates.
The main (M) group of human immunodeficiency virus type 1 (HIV-1) is responsible for the global AIDS epidemic while HIV-1 group O (outlier) and HIV type 2 are endemic only in west and central Africa. The failure of HIV-2 and especially HIV-1 group O to spread following the initial zoonotic jumps is not well understood. This study was designed to examine the relative replicative capacities betwe...
متن کاملACUTE PRIMARY INFECTION WITH A HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1) GROUP O: A PUZZLING DIAGNOSIS. Short title: HIV-1 group O primary infection
1 CHU Clermont-Ferrand, Laboratoire de Virologie, Hôpital Gabriel Montpied, F-63003 Clermont-Ferrand, France 3 CHU Clermont-Ferrand, Service de Maladies Infectieuses et Tropicales, Hôpital Gabriel Montpied, F-63003 Clermont-Ferrand, France 2 Centre Hospitalier Montluçon, Service de Dermatologie, F-03100 Montluçon, France 4 Centre Hospitalier Montluçon, Laboratoire, F-03100 Montluçon, France 5 L...
متن کاملSplicing regulatory elements within tat exon 2 of human immunodeficiency virus type 1 (HIV-1) are characteristic of group M but not group O HIV-1 strains.
In the NL4-3 strain of human immunodeficiency virus type 1 (HIV-1), regulatory elements responsible for the relative efficiencies of alternative splicing at the tat, rev, and the env/nef 3' splice sites (A3 through A5) are contained within the region of tat exon 2 and its flanking sequences. Two elements affecting splicing of tat, rev, and env/nef mRNAs have been localized to this region. First...
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Background: During the recent years, significant progress has been achieved on development of novel anti-viral drugs. Natural products are assumed as the potential sources of novel anti-viral drugs; therefore, there are some previous studies reporting the anti-viral compounds from venomous animals. Based on the significant value for tracing of non-toxic anti-viral agents from natural resources,...
متن کاملReplicative fitness of historical and recent HIV-1 isolates suggests HIV-1 attenuation over time.
BACKGROUND Changes in virulence during an epidemic are common among pathogens, but still unexplored in the case of HIV-1. Here we used primary human cells to study the replicative fitness of primary HIV-1 isolates from untreated patients, comparing historical (1986-1989) and recent samples (2002-2003). METHODS Head-to-head dual virus infection/competition assays were performed in both periphe...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2005
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.79.14.8979-8990.2005